Triethylamine → 2-(2,4-Dinitrophenoxy)-1H-isoindole-1,3(2H)-dione

HRID 876811

反応式

HRID 876811 の反応式
[OH:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12].CCN(CC)CC.Br[C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][C:22]=1[N+:30]([O-:32])=[O:31]>CC(C)=O>[N+:27]([C:24]1[CH:23]=[C:22]([N+:30]([O-:32])=[O:31])[CH:21]=[CH:26][C:25]=1[O:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12])([O-:29])=[O:28]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 10665N-HydroxyphthalimideHCID 114411-Bromo-2,4-dinitrobenzene

生成物 1

HCID 70363092-(2,4-Dinitrophenoxy)-1H-isoindole-1,3(2H)-dione収率 96.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a suspension of 2-hydroxyisoindoline-1,3-dione (20.0 g, 0.12 mol) in acetone (400 mL) was added Et3N (14.9 g, 0.15 mol), the mixture was stirred at room temperature until it became a homogeneous solution, then 1-bromo-2,4-dinitrobenzene Y-1 (30.2 g, 0.12 mol) was added. The reaction was stirred at room temperature for 3 h, then poured into ice-water, the resulting precipitate was filtered and washed three times with cold MeOH, dried in vacuum to afford the title compound (38.1 g).

後処理

  1. stirringThe reaction was stirred at room temperature for 3 h
  2. filtrationthe resulting precipitate was filtered
  3. washwashed three times with cold MeOH
  4. customdried in vacuum

出典と根拠

ORDレコード
ord-dbb3f970c0724ff3a7a479fecd60add1
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

関連ノート

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