Chloroacetaldehyde → Imidazo(1,2-b)pyridazine-6-carboxylic acid
反応式
[NH2:1][C:2]1[N:7]=[N:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.Cl[CH2:12][CH:13]=O>C(O)C>[N:1]1[CH:12]=[CH:13][N:7]2[C:2]=1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6]2参加物
4
実験手順
To a mixture of 6-aminopyridazine-3-carboxylic acid (1-1) (1.39 g, 10 mmol) in ethanol in a sealed flask was added 2-chloroacetaldehyde (4 mL, 40% aqueous). The reaction mixture was stirred at room temperature for 5 min, then heated at 100° C. overnight. After cooled to room temperature, the mixture was concentrated to afford the title compound (1.63 g). MS (m/z): 164 (M+1)+
後処理
- temperatureheated at 100° C. overnight
- temperatureAfter cooled to room temperature
- concentrationthe mixture was concentrated
出典と根拠
- ORDレコード
- ord-8bcf8f3ff5e3442fbc41b005fbb93796
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987269B2
反応ノート
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