Pyrazolo[1,5-a]pyriMidine-5-carbonitrile → Pyrazolo[1,5-a]pyrimidine-5-methanamine

HRID 876821ノート

反応式

HRID 876821 の反応式
[N:1]1[N:5]2[CH:6]=[CH:7][C:8]([C:10]#[N:11])=[N:9][C:4]2=[CH:3][CH:2]=1>N.CO.[Ni]>[N:1]1[N:5]2[CH:6]=[CH:7][C:8]([CH2:10][NH2:11])=[N:9][C:4]2=[CH:3][CH:2]=1

参加物

5

反応物 1

HCID 23156341Pyrazolo[1,5-a]pyriMidine-5-carbonitrile

生成物 1

HCID 67305688Pyrazolo[1,5-a]pyrimidine-5-methanamine収率 94%

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 222Ammonia溶媒HCID 887Methanol溶媒

実験手順

To a solution of pyrazolo[1,5-a]pyrimidine-5-carbonitrile (2-2) (620 mg, 4.31 mmol) in NH3 in MeOH (5 mL) was added Raney Ni (100 mg). The reaction mixture was stirred at room temperature for 3 h under H2. The mixture was filtered, and the filtrate was concentrated to afford the title compound (600 mg). MS (m/z): 149 (M+1)+.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-9894752808144c3a9a1cd7a78ddd6107
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

反応ノート

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