化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 6-((6-(Pyridin-4-ylthio)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4,5,6,7-Tetrahydrothieno(3,2-c)pyridinium chloride | HCID 10176342 | — |
| 反応物 | 6-((5-chloro-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline | HCID 58514601 | — |
| 生成物 | 6-((6-(Pyridin-4-ylthio)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)-quinoline | HCID 67306428 | — |
反応手順
The mixture 6-((5-chloro-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline (60 mg, 0.2 mmol) (prepared according to Compound 60), Cs2CO3 (195 mg, 0.6 mmol) and 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (52 mg, 0.3 mmol) in DMF (1.5 mL) was stirred at 120° C. overnight, then concentrated. The residue was purified by chromatography to afford the title compound MS (m/z): 399 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987269B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-c691621327fa4afd895c94af5d641f9c |
| 出典メモ | uspto-grants-2015_03 |