Triethylamine → 5-Amino-1-ethyl-1H-pyrazole-4-carbonitrile

HRID 876902ノート

反応式

HRID 876902 の反応式
C(OC=C(C#N)[C:6]#[N:7])C.[C:10](O)(=O)[C:11](O)=O.[CH2:16]([NH:18][NH2:19])[CH3:17].[CH2:20]([N:22](CC)CC)C>C(O)C>[NH2:22][C:20]1[N:19]([CH2:10][CH3:11])[N:18]=[CH:16][C:17]=1[C:6]#[N:7]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 671522-(Ethoxymethylene)propanedinitrileHCID 96181Hydrazine, ethyl-, ethanedioate (1:1)

生成物 1

HCID 107967925-Amino-1-ethyl-1H-pyrazole-4-carbonitrile収率 53%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethoxy-methylidenemalononitrile 1b (1.73 g, 14.17 mmol) was added portionwise to a mixture of N-ethylhydrazine oxalate (1 equiv., 2.13 ml) and triethylamine (2.1 equiv., 4.17 ml) in ethanol (20 ml) and the reaction mixture was refluxed for 1 hour, cooled to room temperature, precipitate filtered, washed with ethanol and dried to give 5-amino-1-ethyl-1H-pyrazole-4-carbonitrile 2b as white crystalline solid (1.02 g, 53%).

後処理

  1. temperaturethe reaction mixture was refluxed for 1 hour
  2. filtrationprecipitate filtered
  3. washwashed with ethanol
  4. customdried

出典と根拠

ORDレコード
ord-a7f218b8b3bb407c9c97a29f81b01d08
出典データセット
uspto-grants-2015_03
特許番号
US08987280B2

反応ノート

読み込み中…