4,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidine → (6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methanesulfonyl-benzyl)-amine

HRID 876926

反応式

HRID 876926 の反応式
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][NH2:9])(=[O:4])=[O:3].Cl[C:14]1[N:19]=[C:18]([Cl:20])[N:17]=[C:16]2[N:21]([CH3:24])[N:22]=[CH:23][C:15]=12>>[Cl:20][C:18]1[N:17]=[C:16]2[N:21]([CH3:24])[N:22]=[CH:23][C:15]2=[C:14]([NH:9][CH2:8][C:7]2[CH:10]=[CH:11][CH:12]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=2)[N:19]=1

参加物

3

反応物 2

HCID 2222474,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidineHCID 2760937(3-(Methylsulfonyl)phenyl)methanamine

生成物 1

HCID 58345948(6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methanesulfonyl-benzyl)-amine

実験手順

Reaction of 3-(methylsulfonyl)benzylamine with 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 5 by General Procedure B gave (6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-methanesulfonyl-benzyl)-amine.

出典と根拠

ORDレコード
ord-94f4fc4e38a54c908b770a51e436c90a
出典データセット
uspto-grants-2015_03
特許番号
US08987280B2

関連ノート

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