Sodium Methoxide → N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

HRID 877

反応式

HRID 877 の反応式
F[C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH2:10][S:11][CH3:12])[CH:7]=1.[CH3:19][O-:20].[Na+]>CO>[CH3:19][O:20][C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH2:10][S:11][CH3:12])[CH:7]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 57293179N-(5-Fluoro-2-nitrophenyl)-S-methyl-L-cysteine

生成物 1

HCID 57147352N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

27 g of N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine (0.1 mol) from Example 1 are dissolved in 150 ml of absolute methanol in a four-necked flask, and 14.4 g of 95% sodium methoxide (0.25 mmol) are added in portions, within the space of 20 minutes and under argon, to this solution while stirring well and while cooling by means of an ice bath. The mixture is then heated to reflux for 2 hours while stirring. TLC monitoring then indicates that the reaction is complete.

後処理

  1. temperaturewhile cooling by means of an ice bath
  2. temperatureThe mixture is then heated
  3. temperatureto reflux for 2 hours
  4. stirringwhile stirring

出典と根拠

ORDレコード
ord-49f2d19dd08c44a6a1032e78dc4359e1
出典データセット
uspto-grants-1998_03
特許番号
US05723461

関連ノート

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