Formamide → 5,6-Difluoroisoindoline-1,3-dione
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][C:12]=1[F:13].C([NH2:16])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:11][C:12]=1[F:13])[C:6](=[O:7])[NH:16][C:9]2=[O:8]参加物
3
実験手順
At 130° C., 1.0 g (5.4 mmol) of 4,5-difluorophthalic anhydride was stirred in 6 ml of formamide for 2 h. After cooling, the reaction mixture was then added to ice-cold water. The precipitated yellow solid was filtered off with suction, washed thoroughly with cold water and dried under high vacuum. This gave 744 mg of a white solid (74.8% of theory).
後処理
- temperatureAfter cooling
- additionthe reaction mixture was then added to ice-cold water
- filtrationThe precipitated yellow solid was filtered off with suction
- washwashed thoroughly with cold water
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-202235d35c12483ab53dba07875fb838
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987256B2
反応ノート
読み込み中…