Potassium Carbonate → methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

HRID 877943ノート

反応式

HRID 877943 の反応式
C([O:4][CH2:5][C@H:6]1[O:11][C:10]([CH3:13])([CH3:12])[O:9][C@@H:8]([CH2:14][C:15]([O:17][CH2:18]C)=[O:16])[CH2:7]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C@H:6]1[O:11][C:10]([CH3:12])([CH3:13])[O:9][C@@H:8]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH2:7]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 53339171ethyl 2-((4R,6S)-6-(acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

生成物 1

HCID 10560752methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
5 °C

実験手順

Mixture of ethyl 2-((4R,6S)-6-(acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (80 grams), potassium carbonate (21 grams) in methanol (400 ml) was stirred for 2 hours at 0-10° C. The reaction mixture was quenched with water and then the reaction mixture extracted into methylene chloride and washed it with water. The methylene chloride from the reaction mixture was distilled off under reduced pressure to get the title compound.

後処理

  1. customThe reaction mixture was quenched with water
  2. extractionthe reaction mixture extracted into methylene chloride
  3. washwashed it with water
  4. distillationThe methylene chloride from the reaction mixture was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-479700964776427eaf2efd9b91fe2042
出典データセット
uspto-grants-2015_03
特許番号
US08987444B2

反応ノート

読み込み中…