3,5-Bis(trifluoromethyl)benzoyl chloride → N-(4-iodopyridin-3-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide

HRID 878012ノート

反応式

HRID 878012 の反応式
[I:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][CH3:9].[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[C:15](Cl)=[O:16]>>[I:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N:8]([CH3:9])[C:15](=[O:16])[C:14]1[CH:13]=[C:12]([C:11]([F:26])([F:25])[F:10])[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=1

参加物

3

反応物 2

HCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 706632374-iodo-N-methylpyridin-3-amine

生成物 1

HCID 86670697N-(4-iodopyridin-3-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide

実験手順

The title compound was prepared in analogy to example 25, intermediate a, from (4-iodo-pyridin-3-yl)-methyl-amine and 3,5-bis-trifluoromethyl-benzoyl chloride (CAS RN 785-56-8). Pale yellow liquid (15%). MS (ESI): m/z=475 [M+H]+.

出典と根拠

ORDレコード
ord-72175faff12546bb875e7bc25a427cfc
出典データセット
uspto-grants-2015_03
特許番号
US08987307B2

反応ノート

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