3,5-Bis(trifluoromethyl)benzoyl chloride → N-Methyl-N-(3-methyl-[2,4']bipyridinyl-3'-yl)-3,5-bis-trifluoromethyl-benzamide
反応式
[CH3:1][NH:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][N:10]=1.[F:16][C:17]([F:32])([F:31])[C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=1)[C:21](Cl)=[O:22]>>[CH3:1][N:2]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][N:10]=1)[C:21](=[O:22])[C:20]1[CH:24]=[C:25]([C:27]([F:28])([F:29])[F:30])[CH:26]=[C:18]([C:17]([F:16])([F:31])[F:32])[CH:19]=1参加物
3
実験手順
The title compound was prepared in analogy to example 55, from methyl-(3-methyl-[2,4]bipyridinyl-3′-yl)-amine and 3,5-bis(trifluoromethyl)benzoyl chloride (CAS RN 1271-19-8) and using preparative HPLC for the chromatographic purification. Off-white solid (20%). MS (ESI): m/z=440.4 [M+H]+.
後処理
- customfor the chromatographic purification
出典と根拠
- ORDレコード
- ord-5c987a234990430cac48472350df357a
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987307B2
反応ノート
読み込み中…