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(5-Chloro-2-methylphenyl)boronic acid → N-[4-(5-chloro-2-methyl-phenyl)-pyridin-3-yl]-2,2-dimethyl-propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (5-Chloro-2-methylphenyl)boronic acid | HCID 2773336 | — |
| 反応物 | N-(4-Iodopyridin-3-yl)-2,2-dimethylpropanamide | HCID 10447729 | — |
| 溶媒 | Ethylacetate heptane | HCID 21899848 | — |
| 生成物 | N-[4-(5-chloro-2-methyl-phenyl)-pyridin-3-yl]-2,2-dimethyl-propionamide | HCID 70663288 | — |
反応手順
The title compound was prepared in analogy to example 72, from N-(4-iodo-pyridin-3-yl)-2,2-dimethyl-propionamide (CAS RN 113975-32-9) and 5-chloro-2-methylphenylboronic acid (CAS RN 148839-33-2) and using a gradient of n-heptane:EtOAc (100:0 to 0:100). Light yellow solid (99%). MS (ESI): m/z=303.126 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987307B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-d620593104e74924b11517bf91f926ed |
| 出典メモ | uspto-grants-2015_03 |