(2-Methoxypyridin-3-yl)boronic acid → Methyl 2-(4-(2-methoxypyridin-3-yl)pyridin-3-ylamino)acetate
反応式
FC1C(F)=CC([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][C:10]=2[N:15](CCS(C)(=O)=O)C(=O)C2C=C(C(F)(F)F)N=C(C(F)(F)F)C=2)=C(OC)C=1.[CH3:40][O:41][C:42]1[C:47](B(O)O)=[CH:46][CH:45]=[CH:44][N:43]=1.CCCCCCC.C[CH2:59][O:60][C:61]([CH3:63])=[O:62]>>[CH3:59][O:60][C:61](=[O:62])[CH2:63][NH:15][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][C:9]=1[C:47]1[C:42]([O:41][CH3:40])=[N:43][CH:44]=[CH:45][CH:46]=1参加物
4
実験手順
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-ylamino)-acetic acid methyl ester (example 176, intermediate b) and 2-methoxypyridine-3-boronic acid (CAS RN 163105-90-6) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light yellow oil (73%). MS (ESI): m/z=274.119 [M+H]+.