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3-Bromo-5-fluoropyridine → 3-Fluoro-5-(pyridin-4-yl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromo-5-fluoropyridine | HCID 820206 | — |
| 反応物 | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| 生成物 | 3-Fluoro-5-(pyridin-4-yl)pyridine | HCID 46315823 | — |
反応手順
Prepared from 3-bromo-5-fluoropyridine (439.0 mg, 2.50 mmol) and pyridin-4-ylboronic acid (509.9 mg, 3.73 mmol) according to Method K, except the product was purified by silica gel chromatography (ethyl acetate, Rf=0.21) instead of preparative HPLC: 1H NMR (300 MHz, chloroform-D) δ ppm 7.50-7.51 (m, 2H), 7.65 (dt, J=9.1, 2.4 Hz, 1H), 8.56 (d, J=2.8 Hz, 1H), 8.73-8.76 (m, 3H). MS (DCI/NH3) m/z=175 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987453B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-d4d9c8eab83a4908af0cfc4594124300 |
| 出典メモ | uspto-grants-2015_03 |