1-(3,4-Difluorophenyl)-3-(dimethylamino)prop-2-en-1-one → 2-[5-(3,4-difluorophenyl)-1H-pyrazol-1-yl]pyridine-4-carbonitrile

HRID 878504

反応式

HRID 878504 の反応式
Cl.[NH:2]([C:4]1[CH:9]=[C:8]([C:10]#[N:11])[CH:7]=[CH:6][N:5]=1)[NH2:3].[F:12][C:13]1[CH:14]=[C:15]([C:20](=O)/[CH:21]=[CH:22]/N(C)C)[CH:16]=[CH:17][C:18]=1[F:19]>>[F:12][C:13]1[CH:14]=[C:15]([C:20]2[N:2]([C:4]3[CH:9]=[C:8]([C:10]#[N:11])[CH:7]=[CH:6][N:5]=3)[N:3]=[CH:22][CH:21]=2)[CH:16]=[CH:17][C:18]=1[F:19]

参加物

3

反応物 2

HCID 637061161-(3,4-Difluorophenyl)-3-(dimethylamino)prop-2-en-1-oneHCID 867254842-Hydrazinylpyridine-4-carbonitrile hydrochloride salt

生成物 1

HCID 867254872-[5-(3,4-difluorophenyl)-1H-pyrazol-1-yl]pyridine-4-carbonitrile収率 83%

実験手順

The title compound was prepared in 83% yield from 2-hydrazinylpyridine-4-carbonitrile hydrochloride salt (PREPARATION 3) and (2E)-1-(3,4-difluorophenyl)-3-(dimethylamino)prop-2-en-1-one according to the procedure for the preparation of Example 12, part B. 1H NMR (400 MHz, CDCl3): δ 6.50 (1H, d, J=1.6 Hz), 7.01-7.04 (1H, m), 7.11-7.18 (2H, m), 7.38-7.40 (1H, m), 7.77 (1H, d, J=2.0 Hz), 8.12 (1H, s), 8.36 (1H, d, J=4.8 Hz).

出典と根拠

ORDレコード
ord-070b5d611e8a408685eeeabf0cb4a743
出典データセット
uspto-grants-2015_03
特許番号
US08987461B2

関連ノート

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