2,4-Dimethylbenzyl alcohol → 2-[5-[(2,4-Dimethylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

反応式

[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[CH3:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=1[CH2:23]O>>[CH3:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=1[CH2:23][O:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 278092,4-Dimethylbenzyl alcohol

HCID 178510213HCID 178510213、化合物

生成物 1

HCID 867256272-[5-[(2,4-Dimethylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

実験手順

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and (2,4-dimethylphenyl)methanol according to the procedure for the preparation of Example 39, part C. [M+H] Calc'd for C18H16N4O, 305; Found, 305.

出典と根拠

ORDレコード: ord-d10167a24091412f814b8bdef91ff955
出典データセット: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08987461B2

反応ノート

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