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Water → 2-[1-(4-Cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 2-[4-(2-Hydroxyethyl)pyrazol-1-yl]pyridine-4-carbonitrile | HCID 86725663 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-[1-(4-Cyanopyridin-2-yl)pyrazol-4-yl]ethyl methanesulfonate | HCID 86725665 | 87% |
反応手順
To a mixture of 2-[4-(2-hydroxyethyl)pyrazol-1-yl]pyridine-4-carbonitrile (700 mg, 3.3 mmol), Et3N (670 mg, 6.6 mmol) in DCM (15 mL) was added MeSO2Cl (410 mg, 3.6 mmoL) at 0° C., the mixture was then stirred for 2 hours at room temperature, water was added and extracted with DCM and concentrated give the title compound (830 mg, 87%). [M+H] Calc'd for C12H12N4O3S, 293; Found, 293.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987461B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-9163bf5970ff46958678ead4f7f6e0a3 |
| 出典メモ | uspto-grants-2015_03 |