関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (2-Nitrophenyl)hydrazine | HCID 3314739 | — |
| 反応物 | 2,3-Dioxo-2,3-dihydro-1H-indole-5-sulfonic acid (furan-2-ylmethyl)amide | HCID 59763031 | — |
| 触媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178517309 | HCID 178517309 | — |
反応手順
A mixture of rpm161 (0.040 g, 0.114 mmol) 2-nitrophenylhydrazine (0.021 g, 0.126 mmol, 1.1 eq) and HCl (aq 4 M, 2 drops) in ethanol (3 mL) was heated in the CEM microwave at 120° C. for 15 min. After cooling to room temperature, pure product rpm168 was collected as an orange precipitate by filtration and dried in vacuo. The pure compound rpm168 was obtained without further purification (0.048 g, 0.099 mmol, 86%). MS (API-ES): m/z 459 (M+NH4)+; HRMS (API-ES) m/z Found: 459.1082 (M+NH4)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08987474B2 |
|---|
| 出典データセット | uspto-grants-2015_03 |
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| ORD ID | ord-3013d6af1a784f6da467cae0cdc17c3c |
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| 出典メモ | uspto-grants-2015_03 |
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