Water → 3-Dimethylaminomethylene-2-oxo-2,3-dihydro-1h-indole-5-sulfonic acid

反応式

C(N[S:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11]2)(=[O:7])=[O:6])(C)C.[CH3:18][N:19]([CH:21](OC)OC)[CH3:20].[OH2:26]>CN(C=O)C>[CH3:18][N:19]([CH:21]=[C:11]1[C:10]2[C:14](=[CH:15][CH:16]=[C:8]([S:5]([OH:6])(=[O:7])=[O:26])[CH:9]=2)[NH:13][C:12]1=[O:17])[CH3:20]

参加物

実験手順

A solution of rpm281 (0.180 g, 0.708 mmol) and N,N-dimethylformamidedimethylacetal (0.125 g, 0.85 mmol, 1.2 eq) in DMF (2 ml) was stirred for 1 h at room temperature. Water (7 ml) was added and the product extracted with ethyl acetate (3×10 ml). The organic extracts were collected, dried over Na2SO4 and the solvent evaporated under reduced pressure to give a yellow solid, which was used in the next step without further purification.