Potassium Hydroxide → potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

HRID 878996ノート

反応式

HRID 878996 の反応式
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[OH-].[K+:25]>C(O)C>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:14][C:15]([O-:17])=[O:16])[CH:12]=2)[C:7]([CH3:18])=[N:6]1.[K+:25]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 60152151HCID 60152151、化合物

生成物 1

HCID 131732622potassium 2-[1-(2,6-dichlorobenzyl)-3-methyl-1H-indazole-6-yl]acetate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the compound [97](118 mg) in ethanol (5 mL) was added an aqueous solution of 1N-potassium hydroxide (0.34 mL) at room temperature, and then the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to give the titled compound (128 mg) as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-3b0f27bfeff34be3a00018d1257bb4fd
出典データセット
uspto-grants-2015_03
特許番号
US08987473B2

反応ノート

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