5-Bromo-3-fluoropyridine-2-carbonitrile → HCID 178437984、化合物

HRID 879011ノート

反応式

HRID 879011 の反応式
[Br:1][C:2]1[CH:3]=[C:4](F)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH2:11]([Mg]Cl)[CH3:12].ClC1C=CC=C(Cl)C=1C[N:19]1C2C(=NC=C(C(O)=O)C=2)C(C)=N1>>[Br:1][C:2]1[CH:3]=[C:4]2[NH:19][N:9]=[C:8]([CH2:11][CH3:12])[C:5]2=[N:6][CH:7]=1

参加物

4

反応物 3

HCID 441966805-Bromo-3-fluoropyridine-2-carbonitrileHCID 681838111-(2,6-dichlorobenzyl)-3-methyl-1H-pyrazolo[4,3-b]pyridine-6-carboxylic acidHCID 178461633HCID 178461633、化合物

生成物 1

HCID 178437984HCID 178437984、化合物

実験手順

The titled compound (225 mg) as a white solid was prepared from 5-bromo-3-fluoropyridin-2-carbonitrile (201 mg) obtained by the method described in the document (Journal of Organic Chemistry, 2009, Vol. 74, p. 4547) and ethylmagnesium chloride according to the methods of the processes (1) and (2) of Example 153.

後処理

  1. customobtained by the method

出典と根拠

ORDレコード
ord-a90160fa915f486fa7ce01beb295c1c4
出典データセット
uspto-grants-2015_03
特許番号
US08987473B2

反応ノート

読み込み中…