5-Methylindoline → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(5-methylindolin-1-yl)benzo[d]thiazol-6-yl)acetic acid

関与物質

反応手順

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(5-methylindolin-1-yl)benzo[d]thiazol-6-yl)acetic acid was prepared in similar manner as (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-(3-oxo-1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)pyridin-4-yl)benzo[d]thiazol-6-yl)acetic acid except (S)-ethyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate was used instead of (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate, 5-Methylindoline was used instead 1H-pyrrolo[3,4-c]pyridin-3(2H)-one and Pd(P-tBu3)2 was used instead of Pd2(dba)3. LCMS-ESI+: C29H30ClN2O3S: 521.2 (M+H+); Found: 521.2 (M+H+); 1H NMR (400 MHz, CD3OD) δ: 7.75 (s, 1H), 7.67-7.64 (m, 1H), 7.57-7.50 (m, 3H), 7.44 (s, 1H), 7.12 (d, 1H), 6.84 (d, 1H), 5.17 (s, 1H), 4.07 (dd, 2H), 3.19 (dd, 2H), 2.53 (s, 3H), 2.35 (s, 3H), 0.95 (s, 9H).

情報源と証拠