Trimethylsilyldiazomethane → HCID 75445982、化合物

HRID 879704ノート

反応式

HRID 879704 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][C:11]([C:15]([OH:17])=[O:16])=[C:12]([CH3:14])[N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Si](C=[N+]=[N-])(C)(C)[CH3:19]>C1COCC1.CO>[CH3:19][O:16][C:15]([C:11]1[S:10][C:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])=[N:13][C:12]=1[CH3:14])=[O:17]

参加物

4

反応物 2

HCID 167693TrimethylsilyldiazomethaneHCID 2756770N-Boc-amino-4-methylthiazole-5-carboxylic acid

生成物 1

HCID 75445982HCID 75445982、化合物

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

2-tert-Butoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid (0.52 g) was dissolved in THF: MeOH (2:1, 10 mL) and 2 eq of TMSCHN2 (2M sln in hex) was added at RT and stirred for 6 h. All volatiles were removed in vacuum by rotavap and the residue was dried in vacuum to give 2-tert-Butoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid methyl ester (0.52 g). This was used in the next reaction without further purification. 1H NMR (400 MHz, CDCl3) 3.83 (s, 3H), 2.65 (s, 3H), 1.54 (s, 9H).

後処理

  1. customAll volatiles were removed in vacuum by rotavap
  2. customthe residue was dried in vacuum

出典と根拠

ORDレコード
ord-5a5b606ced7b425ea07c158f5cec6b64
出典データセット
uspto-grants-2015_03
特許番号
US08987295B2

反応ノート

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