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Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 2-Amino-4-methyl-5-nitropyridine | HCID 243165 | — |
| 生成物 | N-(4-methyl-5-nitropyridin-2-yl)acetamide | HCID 13567013 | — |
反応手順
4-Methyl-5-nitro-pyridin-2-ylamine (1.0 g) was treated with acetic anhydride according to General Procedure Y to give N-(4-Methyl-5-nitro-pyridin-2-yl)-acetamide (1.1 g). LCMS (m/z): 196. N-(4-Methyl-5-nitro-pyridin-2-yl)acetamide (0.5 g) was reduced under hydrogen atmosphere according to General Procedure Z to give N-(5-Amino-4-methyl-pyridin-2-yl)-acetamide (0.4 g), LCMS (m/z): 166. This was converted to 6-acetylamino-4-methyl-pyridine-3-sulfonyl chloride (0.35 g) according to General Procedure AA. LCMS (m/z): 249.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987295B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-4c76b1ae96b948a2be5c70de633b7e2c |
| 出典メモ | uspto-grants-2015_03 |