Triethylamine → HCID 86730085、化合物

HRID 880032ノート

反応式

HRID 880032 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C@H:12]([NH2:19])[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].C[O:21][C:22]1[C:23](=[O:32])[N:24]([CH3:31])[CH:25]=[CH:26][C:27]=1[C:28](Cl)=[O:29].CCN(CC)CC>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C@H:12]([NH:19][C:28]([C:27]3[CH:26]=[CH:25][N:24]([CH3:31])[C:23](=[O:32])[C:22]=3[OH:21])=[O:29])[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 40418811cis-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine2 回HCID 867300823-Methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carbonyl chloride2 回

生成物 1

HCID 86730085HCID 86730085、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine (10 mg, 0.034 mmol) (Intermediate 16) and 3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carbonyl chloride (Intermediate 12A) (6.90 mg, 0.034 mmol) in DCM (1 mL) was added Et3N (0.014 mL, 0.10 mmol). The reaction mixture was stirred for 2 h. The reaction mixture was quenched with H2O and DCM. The DCM portion was dried over Na2SO4, filtered and the solvent removed under reduced pressure to give Example 8A which was used without further purification.

後処理

  1. customThe reaction mixture was quenched with H2O and DCM
  2. dry with materialThe DCM portion was dried over Na2SO4
  3. filtrationfiltered
  4. customthe solvent removed under reduced pressure
  5. customto give Example 8A which
  6. customwas used without further purification

出典と根拠

ORDレコード
ord-84416f55946240f09a769cae266066ec
出典データセット
uspto-grants-2015_03
特許番号
US08993557B2

反応ノート

読み込み中…