Triethylamine → HCID 178523576、化合物

HRID 880034

反応式

HRID 880034 の反応式
[OH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[CH:6][C:7]=1[C:8](Cl)=[O:9].[C:12]1([C@@H:18]2[CH2:23][CH2:22][C@H:21]([NH2:24])[CH2:20][CH2:19]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.CCN(CC)CC>C(Cl)Cl>[OH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[CH:6][C:7]=1[C:8]([NH:24][C@H:21]1[CH2:20][CH2:19][C@@H:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:23][CH2:22]1)=[O:9]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 867300873-Hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride2 回HCID 178418405HCID 178418405、化合物2 回

生成物 1

HCID 178523576HCID 178523576、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride (Intermediate 17) (38.1 mg, 0.219 mmol) and cis-4-phenylcyclohexanamine (Intermediate 14) (50 mg, 0.29 mmol) in DCM (1 mL) was added Et3N (0.061 mL, 0.44 mmol). The reaction mixture was stirred at rt for 1 h. The reaction mixture was partitioned between H2O and DCM. The DCM layer was dried over Na2SO4 and filtered through a silica gel plug. The solvent was removed under reduced pressure to give Example 36A which was used without further purification.

後処理

  1. customThe reaction mixture was partitioned between H2O and DCM
  2. dry with materialThe DCM layer was dried over Na2SO4
  3. filtrationfiltered through a silica gel plug
  4. customThe solvent was removed under reduced pressure
  5. customto give Example 36A which
  6. customwas used without further purification

出典と根拠

ORDレコード
ord-44906a32281c4353b07466489919940a
出典データセット
uspto-grants-2015_03
特許番号
US08993557B2

関連ノート

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