Acetic Acid → HCID 15987642、化合物

HRID 880045ノート

反応式

HRID 880045 の反応式
[C:1]1([N:7]2[C:12](=[O:13])[N:11]([CH3:14])[C:10](=[O:15])C(C#N)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C:19]([OH:22])(=[O:21])[CH3:20]>>[C:1]1([N:7]2[C:12](=[O:13])[N:11]([CH3:14])[C:10](=[O:15])[C:20]([C:19]([OH:22])=[O:21])=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 47801582-Phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

生成物 1

HCID 15987642HCID 15987642、化合物収率 45.7%

反応条件

温度
120 °C

実験手順

Intermediate d (7.6 g, 0.033 mol) was added to a mixed solvent of glacial acetic acid (100 mL) and HCl (72 mL, 0.86 mol). The mixture was warmed up to 120° C. and reacted under reflux for 4 h. The solvent was evaporated off. To the obtained fraction was added water (400 mL). The mixture was filtered by suction and dried to produce a solid (3.7 g) in a yield of 45.7%.

後処理

  1. customreacted
  2. temperatureunder reflux for 4 h
  3. customThe solvent was evaporated off
  4. additionTo the obtained fraction was added water (400 mL)
  5. filtrationThe mixture was filtered by suction
  6. customdried

出典と根拠

ORDレコード
ord-27446c6adc684d779ed9b5bddb6714a1
出典データセット
uspto-grants-2015_03
特許番号
US08993566B2

反応ノート

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