Bromine → 2-Bromo-1-(2-isopropoxyphenyl)ethanone
反応式
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:13])[CH3:12])([CH3:3])[CH3:2].[Br:14]Br>CCOCC>[Br:14][CH2:12][C:11]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[O:4][CH:1]([CH3:3])[CH3:2])=[O:13]参加物
4
実験手順
Dissolve 1-(2-isopropoxyphenyl)ethanone (1.0 g, 6 mmol) in Et2O (25 mL) and add bromine (0.3 mL, 6 mmol) drop-wise while stirring stir the mixture in the dark at ambient temperature. Wash the reaction mixture with a saturated aqueous Na2CO3 solution. Dry it over MgSO4; filter; collect the filtrate; removed the volatiles under reduced pressure to provide the title compound (1.5 g, 83%). MS (m/z): 258 (M+1).
後処理
- stirringstir the mixture in the dark at ambient temperature
- washWash the reaction mixture with a saturated aqueous Na2CO3 solution
- dry with materialDry it over MgSO4
- filtrationfilter
- customcollect the filtrate
- customremoved the volatiles under reduced pressure
出典と根拠
- ORDレコード
- ord-e253c7b8d67a4f84a2ca2f7cfa147806
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993568B2
反応ノート
読み込み中…