Ammonia → 1-amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
反応式
[O:1]1[CH2:3][CH:2]1[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1.[NH3:15]>CCO>[NH2:15][CH2:3][CH:2]([OH:1])[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of 2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline (17 g, 0.09 mol) in EtOH (300 mL) at −78° C. was slowly bubbled NH3 (g). The reaction mixture was then sealed and heated at 80° C. for 3 h. The reaction mixture was concentrated and the crude product was used in next step without further purification (18 g, Yield 96%). LCMS (m/z): 207.1 (M+1).
後処理
- customat −78° C.
- customThe reaction mixture was then sealed
- concentrationThe reaction mixture was concentrated
- customthe crude product was used in next step without further purification (18 g, Yield 96%)
出典と根拠
- ORDレコード
- ord-084f722f8b7340a488101033438cd514
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993555B2
反応ノート
読み込み中…