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Sodium Carbonate → 2,2'-(6-Oxo-1-(1-phenylethyl)-1,6-dihydropyridazine-4,5-diyl)dibenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 3570229 | — |
| 反応物 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 反応物 | 4,5-dichloro-2-(1-phenylethyl)pyridazin-3(2H)-one | HCID 68013986 | — |
| 触媒 | Palladium Chloride | HCID 24290 | — |
| 生成物 | 2,2'-(6-Oxo-1-(1-phenylethyl)-1,6-dihydropyridazine-4,5-diyl)dibenzonitrile | HCID 57385631 | 3.4% |
反応手順
Compound 4 is prepared from the intermediate 1a and 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile according to step 1 of the method of synthesis using PdCl2/2PPh3, Na2CO3 and a mixture of water/acetonitrile: 1/1. The minor product formed corresponds to compound 4 (yield: 3.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08993569B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-df0cc13c5705491984ec678e116cfc26 |
| 出典メモ | uspto-grants-2015_03 |