Potassium Cyanide → 2-(Propan-2-yl)butanedinitrile

HRID 880421ノート

反応式

HRID 880421 の反応式
[C-:1]#[N:2].[K+].[C:4]([C:6](=[CH:12][CH:13]([CH3:15])[CH3:14])C(OCC)=O)#[N:5]>O.C(O)C>[CH:13]([CH:12]([CH2:6][C:4]#[N:5])[C:1]#[N:2])([CH3:14])[CH3:15]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 54168338HCID 54168338、化合物

生成物 1

HCID 1368682-(Propan-2-yl)butanedinitrile収率 74%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of potassium cyanide (5.81 g, 89.52 mmol) in water (12 mL) was added to a solution of ethyl 2-cyano-4-methyl-pent-2-enoate (6.5 g, 38.92 mmol) in ethanol (20 mL) at room temperature and the reaction mixture was stirred overnight. The resulting mixture was refluxed for 2 h and then cooled to room temperature. The ethanol was evaporated and the residue dissolved in dichloromethane. The dichloromethane layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-isopropylbutanedinitrile (3.5 g, 74%) as a liquid.

後処理

  1. temperatureThe resulting mixture was refluxed for 2 h
  2. customThe ethanol was evaporated
  3. dissolutionthe residue dissolved in dichloromethane
  4. washThe dichloromethane layer was washed with water and brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-b613ab7d7e274f93bf3ca0d5c5e81b17
出典データセット
uspto-grants-2015_03
特許番号
US08993574B2

反応ノート

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