Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

関与物質

反応手順

N-bromosuccinimide (910 mg, 5.1 mmol) was added at room temperature to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL). The mixture was stirred at reflux to 18 h. The reaction mixture was then filtered through celite and concentrated to give the title compound, which was used in the next step without further purification.

情報源と証拠