7-Bromo-3-methoxyisoquinoline → 3-Methoxyisoquinoline-7-carboxylic acid
反応式
FC(F)(F)[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=[C:7]2[C:11]=1N[N:9]=[CH:8]2.BrC1C=C2C([CH:22]=[C:23]([O:28][CH3:29])N=C2)=CC=1>>[CH3:29][O:28][C:23]1[N:9]=[CH:8][C:7]2[C:11]([CH:22]=1)=[CH:3][CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=2参加物
3
実験手順
The title compound was prepared by a method analogous to that described in Steps 3-4 of Intermediate 21, using 7-bromo-3-methoxyisoquinoline. +ESI (M+H) 204.2; 1H NMR (400 MHz, CD3OD, δ): 9.08 (s, 1H), 8.71 (s, 1H), 8.14 (dd, J=8.78, 1.56 Hz, 1H), 7.83 (d, J=8.78 Hz, 1H), 7.17 (s, 1H), 4.02 (s, 3H).
出典と根拠
- ORDレコード
- ord-9a6a88c60ae6462994cfaa949b06a6bb
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993586B2
反応ノート
読み込み中…