1-(Methylamino)isoquinoline-7-carboxylic acid → Ethyl 1-(methylamino)isoquinoline-6-carboxylate
反応式
[CH3:1][NH:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10](C(O)=O)[CH:11]=2)[CH:6]=[CH:5][N:4]=1.ClC1C2C(=CC([C:27]([O:29][CH2:30][CH3:31])=[O:28])=CC=2)C=CN=1>>[CH3:1][NH:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1参加物
3
実験手順
The title compound was prepared by a method analogous to that described in Step 1 of Intermediate 31, using ethyl 1-chloroisoquinoline-6-carboxylate. +ESI (M+H) 231.1; 1H NMR (400 MHz, CDCl3, δ): 8.39 (s, 1H), 8.06-8.14 (m, 2H), 8.00 (d, J=5.9 Hz, 1H), 7.02 (d, J=6.0 Hz, 1H), 4.44 (q, J=7.3 Hz, 2H), 3.25 (d, J=4.7 Hz, 3H), 1.43 (t, J=7.1 Hz, 3H).
出典と根拠
- ORDレコード
- ord-12e0fb0e57344e388c96ddbe3d88e997
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993586B2
反応ノート
読み込み中…