Glycine → (3-Nitro-pyridin-2-ylamino)-acetic acid
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[NH2:17][CH2:18][C:19]([OH:21])=[O:20]>CCO.O>[N+:8]([C:7]1[C:2]([NH:17][CH2:18][C:19]([OH:21])=[O:20])=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]参加物
6
反応条件
- 温度
- 0 °C
実験手順
2-Chloro-3-nitropyridine (5 g, 31.5 mmol) was dissolved in EtOH (125 ml), added potassium carbonate (4.35 g, 31.5 mmol) and to this mixture glycine (4.73 g, 6.3 mmol) in 25 ml water was added and refluxed for overnight. The reaction mixture cooled to 0° C. to obtain the solid. Then EtOH was removed on rotavapour and acidified with 2N HCl and solid filtered and dried on vacuum to obtain the title compound quantitatively as a yellow solid.
後処理
- temperaturerefluxed for overnight
- customto obtain the solid
- customThen EtOH was removed on rotavapour
- filtrationfiltered
- customdried on vacuum
出典と根拠
- ORDレコード
- ord-7c5f66d7d2eb4c84a09dd6c8c4b16539
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993612B2
反応ノート
読み込み中…