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Acetonitrile → 4-Amino-4'-propylazobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Benzenamine, 2-(2-phenyldiazenyl)- | HCID 76077 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Amino-4'-propylazobenzene | HCID 23513408 | — |
反応手順
To a solution of the aminoazobenzene (1 eq) and DIPEA (2 eq) in 1:1 MeCN:DMF at 0° C. was added 2-triethylammonium acetic acid chloride chloride8 (1.5 eq) in 1:1 MeCN:DMF and stirred for 15 min, then warmed to ambient temperature and stirred for 1-12 h at which time the solvent was removed in vacuo for purification by reverse phase silica gel chromatography (0.1% formic acid in H2O, gradient up to 50% MeCN: 0.1% formic acid in H2O).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08993736B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-6485a541c44e4403a60b8eb8b2530f9f |
| 出典メモ | uspto-grants-2015_03 |