Acetoxyacetyl chloride → N-[6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-(pyridin-3-ylcarbonyl)furo[2,3-b]pyridin-3-yl]-2-hydroxyacetamide

HRID 8818ノート

反応式

HRID 8818 の反応式
[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)[CH:9]=2)[O:4][C:3]=1[C:25]([C:27]1[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=1)=[O:26].C([O:36][CH2:37][C:38](Cl)=[O:39])(=O)C>>[Cl:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:7]1[N:6]=[C:5]2[O:4][C:3]([C:25]([C:27]3[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=3)=[O:26])=[C:2]([NH:1][C:37](=[O:36])[CH2:38][OH:39])[C:10]2=[CH:9][C:8]=1[C:11]1[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=1

参加物

3

反応物 2

HCID 26297Acetoxyacetyl chlorideHCID 21984803[3-Amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)furo[2,3-b]pyridin-2-yl](pyridin-3-yl)methanone

生成物 1

HCID 21984896N-[6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-(pyridin-3-ylcarbonyl)furo[2,3-b]pyridin-3-yl]-2-hydroxyacetamide

実験手順

Using the general acylating procedure described in Example 18, the product of Example 157 was reacted with acetoxyacetyl chloride and then subjected to the general ester hydrolysis procedure described in Example 25 to afford the title compound. HPLC/MS: 518.0 (M+1), 520.0 (M+3); Rt=3.52 min.

出典と根拠

ORDレコード
ord-c381bed665bb4627a586bfbdff44fdf8
出典データセット
uspto-grants-2006_08
特許番号
US07091216B2

反応ノート

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