Hydrochloric Acid → HCID 66629751、化合物

HRID 882336ノート

反応式

HRID 882336 の反応式
[ClH:1].[C:2]1([C@@H:8]2[CH2:10][C@H:9]2[NH:11][CH2:12][C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOCC>[ClH:1].[C:2]1([C@@H:8]2[CH2:10][C@H:9]2[NH:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]#[N:18])=[CH:19][CH:20]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 46869800HCID 46869800、化合物

生成物 1

HCID 66629751HCID 66629751、化合物収率 84.5%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
-78 °C

実験手順

2 M ethereal solution of HCl (0.14 mL, 0.27 mmol) was slowly added to a solution of 4-({[(trans)-2-phenylcyclopropyl]amino}methyl)benzonitrile (67 mg, 0.27 mmol) in dry Et2O (5 mL) cooled at −78° C., and allowed to reach room temperature. After 10 min the white precipitate was allowed to settle and Et2O was decanted, the solid was washed with Et2O (20 mL) and vacuum dried, rendering 65 mg of 4-({[(trans)-2-phenylcyclopropyl]amino}methyl)benzonitrile hydrochloride (white solid, 84% yield).

後処理

  1. customto reach room temperature
  2. customEt2O was decanted
  3. washthe solid was washed with Et2O (20 mL) and vacuum
  4. customdried

出典と根拠

ORDレコード
ord-9fa84ba054ce4cf3815844a8ffbcbb36
出典データセット
uspto-grants-2015_03
特許番号
US08993808B2

反応ノート

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