Hydrochloric Acid → N-[(1R,3S,4S)-1-(2-Aza-bicyclo[2.2.1]hept-3-yl)methyl]-2,2,2-trifluoro-acetamide
反応式
Cl.C(OC([N:9]1[C@H:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])[C@@H:13]2[CH2:23][C@H:10]1[CH2:11][CH2:12]2)=O)(C)(C)C>O1CCOCC1>[C@H:10]12[CH2:23][C@H:13]([CH2:12][CH2:11]1)[C@@H:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([F:20])([F:21])[F:19])[NH:9]2参加物
4
実験手順
A solution of HCl in dioxane (4 M, 40 mL) is added to a solution of (1R,3S,4S)-3-[(2,2,2-trifluoro-acetylamino)-methyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (12.0 mmol) in dioxane (15 mL). After 3 h the solvents are removed in vacuo to give the desired product as a brownish solid which is used without further purification in the next step. LC-MS (basic): tR=0.69 min; [M+H]+=223.2.
後処理
- customAfter 3 h the solvents are removed in vacuo
出典と根拠
- ORDレコード
- ord-2b2d10562b684640a4ac4c480d97ca56
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08236801B2
反応ノート
読み込み中…