化工社化工社 化学情報印刷レポート · 研究参考用
Toluene → 3-chloro-1H-quinoxalin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2,3-Dihydroxyquinoxaline | HCID 27491 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-chloro-1H-quinoxalin-2-one | HCID 302705 | — |
反応手順
The quinoxalin-2-one of the present example is prepared with phenyl-1,2-diamine and oxalic acid via the method described in Example 12 to afford the 1,4-Dihydro quinoxaline-2,3-dione. The 1,4-Dihydro quinoxaline-2,3-dione is then treated with SOCl2 in 2.5% DMF:toluene, heated to 130° C., stirred for 2 h, filtered and concentrated to afford the 3-chloro-1H-quinoxalin-2-one in crude form.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08236807B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-031c6e8730de4d5a887aa11efd4b647c |
| 出典メモ | uspto-grants-2012_08 |