Benzyl Bromide → 6-benzyloxy-3-thiophen-2-yl-1H-quinoxalin-2-one

HRID 882872ノート

反応式

HRID 882872 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[C:6]([C:13]1[S:14][CH:15]=[CH:16][CH:17]=1)=[N:5]2.Br[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:19]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[C:6]([C:13]1[S:14][CH:15]=[CH:16][CH:17]=1)=[N:5]2)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 210836646-hydroxy-3-thiophen-2-yl-1H-quinoxalin-2-one

生成物 1

HCID 210836616-benzyloxy-3-thiophen-2-yl-1H-quinoxalin-2-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The quinoxalin-2-one of the present example is prepared treating 6-hydroxy-3-thiophen-2-yl-1H-quinoxalin-2-one from Example 43 in DMF with bromomethyl benzene in the presence of K2CO3 at a temperature between 25° C. to 80° C. The resulting reaction mixture, after workup and purification, affords 6-benzyloxy-3-thiophen-2-yl-1H-quinoxalin-2-one.

後処理

  1. customThe resulting reaction mixture
  2. customafter workup and purification

出典と根拠

ORDレコード
ord-895beee656a4412dae069e322cedb32f
出典データセット
uspto-grants-2012_08
特許番号
US08236807B2

反応ノート

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