化工社化工社 化学情報印刷レポート · 研究参考用
Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diphenylsilane | HCID 69888 | — |
| 反応物 | (4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone | HCID 48474115 | — |
| 触媒 | Carbonyltris(triphenylphosphine)rhodium(I)hydride | HCID 53249357 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(4-Bromo-3-fluorobenzyl)morpholine | HCID 53417818 | — |
反応手順
A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08236799B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-843b16ae77e44d478946b8a4599c9546 |
| 出典メモ | uspto-grants-2012_08 |