関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzhydrylamine | HCID 7036 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | methyl 3-chlorosulfonyl-2(R)-methylpropionate | HCID 18738451 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | methyl 3-[N-(diphenylmethyl) aminosulfonyl]-2(R)-methylpropionate | HCID 18738453 | 66.4% |
反応手順
A 100 mL round bottom flask equipped with magnetic stir bar was charged with 1 g aminodiphenylmethane, 2 mL triethylamine in 20 mL CH2Cl2. The reaction was cooled to 0° C. and 1 g of methyl 3-chlorosulfonyl-2(R)-methylpropionate was slowly added. The reaction was stirred 1 hour then concentrated in vacuo. The residue was partioned between ethyl acetate and water. The organic phase was washed with brine, dried, and concentrated in vacuo. Trituration from Et2O/hexanes gave 1.15 g of methyl 3-[N-(diphenylmethyl) aminosulfonyl]-2(R)-methylpropionate as a white solid. HRMS (M+Li): calcd. 354.1351, obs 354.1569.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07091219B2 |
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| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-defc4ba15708436b96ff3719a741c0e0 |
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| 出典メモ | uspto-grants-2006_08 |
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