Water → HCID 86601048、化合物

HRID 883541ノート

反応式

HRID 883541 の反応式
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[S:12])[NH:5][C:4](=[O:13])[CH:3]=1.[N:14]([O-])=[O:15].[Na+].O>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[S:12])[NH:5][C:4](=[O:13])[C:3]=1[N:14]=[O:15]

参加物

5

反応物 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 866010496-Amino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

生成物 1

HCID 86601048HCID 86601048、化合物収率 96.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
75 °C

実験手順

6-Amino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.0 g, 5.0 mmol) was suspended in 10% acetic acid (20 mL). Sodium nitrite (0.38 g, 5.5 mmol) was added and the resulting mixture was heated at 75° C. for 1 h. The reaction mixture became first pink and then purple. The purple mixture was cooled to room temperature. Then water (20 mL) was added and the purple solid was collected by filtration and washed with water to give the title compound (1.1 g, 92% yield). This solid was used in the following step without further purification.

後処理

  1. temperatureThe purple mixture was cooled to room temperature
  2. filtrationthe purple solid was collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-8ee2ec76a5224efcb3b19d25b53f3da5
出典データセット
uspto-grants-2012_08
特許番号
US08236951B2

反応ノート

読み込み中…