Formic Acid → HCID 86601051、化合物

HRID 883545

反応式

HRID 883545 の反応式
[NH2:1][C:2]1[C:3](=[O:14])[NH:4][C:5](=[S:13])[N:6]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7]=1[NH2:8].O.[CH:16](O)=[O:17]>>[NH2:8][C:7]1[N:6]([CH2:9][CH:10]([CH3:11])[CH3:12])[C:5](=[S:13])[NH:4][C:3](=[O:14])[C:2]=1[NH:1][CH:16]=[O:17]

参加物

4

反応物 3

HCID 284Formic AcidHCID 962WaterHCID 866010505,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

生成物 1

HCID 86601051HCID 86601051、化合物収率 86%

実験手順

5,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (Example 6 (c), 0.25 g, 1.2 mmol) was dissolved in formic acid (1.5 mL) and stirred at ambient temperature for 0.5 h. A pink precipitate started to form after a few minutes. Water was added and the resulting mixture stirred for 10 minutes. The pink solid was collected by filtration, washed with water and dried to yield the title compound (0.25 g, 86%). This material was used without further purification. NMR showed that the product was obtained as a mixture of two tautomers: formamide (major) and imino (minor).

後処理

  1. customto form after a few minutes
  2. stirringthe resulting mixture stirred for 10 minutes
  3. filtrationThe pink solid was collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-76865c3601e54770a4c6e970617cd5d6
出典データセット
uspto-grants-2012_08
特許番号
US08236951B2

関連ノート

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