Formic Acid → 3-Isobutyl-7-methyl-2-thioxanthine
反応式
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[S:12])[NH:5][C:4](=[O:13])[C:3]=1[NH:14][CH3:15].[CH:16](O)=O>>[CH2:8]([N:7]1[C:2]2[N:1]=[CH:15][N:14]([CH3:16])[C:3]=2[C:4](=[O:13])[NH:5][C:6]1=[S:12])[CH:9]([CH3:11])[CH3:10]参加物
3
反応条件
- 温度
- 85 °C
実験手順
6-Amino-1-isobutyl-5-methylamino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (0.11 g, 0.48 mmol) was dissolved in formic acid (1 mL) and heated at 85° C. for 1 h. The excess of formic acid was evaporated off under reduced pressure. 10% Sodium hydroxide solution (2 mL) was added and the solution was heated at 85° C. for 20 minutes. Water was added and the pH was adjusted to 4 with dilute acetic acid, upon which a white solid precipitated. The white solid was collected by filtration, washed with water and dried to yield the title compound (85 mg, 74%).