Ethanol → 3-(3-Methoxypropyl)-2-thioxanthine

HRID 883550ノート

反応式

HRID 883550 の反応式
[NH2:1][C:2]1[C:3](=[O:17])[NH:4][C:5](=[S:16])[N:6]([CH2:9][CH:10]2CCCC[CH2:11]2)[C:7]=1[NH2:8].[CH:18](OCC)(OCC)[O:19]CC.[CH2:28](O)C>>[CH3:18][O:19][CH2:11][CH2:10][CH2:9][N:6]1[C:7]2[N:8]=[CH:28][NH:1][C:2]=2[C:3](=[O:17])[NH:4][C:5]1=[S:16]

参加物

4

反応物 3

HCID 702EthanolHCID 31214Ethyl orthoformateHCID 86601053HCID 86601053、化合物

生成物 1

HCID 103542623-(3-Methoxypropyl)-2-thioxanthine収率 9%

実験手順

5,6-Diamino-1-cyclohexylmethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.6 g, 12.2 mmol) was dissolved in ethanol (10 mL) and triethyl orthoformate (10 mL) and the reaction mixture was refluxed for 2.5 h. The solvents were evaporated off and the resulting brown solid was purified by flash chromatography (heptane/ethyl acetate, 4:1-1:1) to give the title compound (110 mg, 9%).

後処理

  1. customThe solvents were evaporated off
  2. customthe resulting brown solid was purified by flash chromatography (heptane/ethyl acetate, 4:1-1:1)

出典と根拠

ORDレコード
ord-bab2a1909e9c4c839b29f24efb4f6a4e
出典データセット
uspto-grants-2012_08
特許番号
US08236951B2

反応ノート

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