Methylamine → 1-Isobutyl-3-methylthiourea

HRID 883552

反応式

HRID 883552 の反応式
[CH3:1][NH2:2].[CH2:3]([N:7]=[C:8]=[S:9])[CH:4]([CH3:6])[CH3:5]>>[CH2:3]([NH:7][C:8]([NH:2][CH3:1])=[S:9])[CH:4]([CH3:6])[CH3:5]

参加物

3

反応物 2

HCID 6329MethylamineHCID 68960Isobutyl isothiocyanate

生成物 1

HCID 155682431-Isobutyl-3-methylthiourea収率 98.2%

実験手順

Methylamine (2M in methanol, 20.0 mL, 40.2 mmol) was added dropwise to isobutylisothiocyanate (2.00 mL, 16.5 mmol) during 15 minutes at room temperature. The reaction mixture was heated to reflux for 3.5 h and the solvent was evaporated off to give the title compound (2.37 g, 98%) as a colourless oil.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 3.5 h
  3. customthe solvent was evaporated off

出典と根拠

ORDレコード
ord-a009c415bc374a209f29a2f4261b069c
出典データセット
uspto-grants-2012_08
特許番号
US08236951B2

関連ノート

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