Sodium Nitrite → HCID 86601058、化合物

HRID 883555ノート

反応式

HRID 883555 の反応式
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][O:10]2)[C:6](=[S:14])[NH:5][C:4](=[O:15])[CH:3]=1.[N:16]([O-])=[O:17].[Na+]>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][O:10]2)[C:6](=[S:14])[NH:5][C:4](=[O:15])[C:3]=1[N:16]=[O:17]

参加物

4

反応物 2

HCID 23668193Sodium NitriteHCID 252523746-Amino-2,3-dihydro-1-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4(1H)-pyrimidinone

生成物 1

HCID 86601058HCID 86601058、化合物収率 90.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
75 °C

実験手順

6-Amino-1-(2-tetrahydrofuryl-methyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.3 g, 5.6 mmol) was suspended in 10% aqueous acetic acid (25 mL). Sodium nitrite (0.43 g, 6.2 mmol) was added and this mixture was heated at 75° C. for 1 h. The purple solid was collected by filtration, washed and dried, giving the title product (1.3 g, 90%).

後処理

  1. filtrationThe purple solid was collected by filtration
  2. washwashed
  3. customdried

出典と根拠

ORDレコード
ord-9e591c55494f4109840b997130524381
出典データセット
uspto-grants-2012_08
特許番号
US08236951B2

反応ノート

読み込み中…