化工社化工社 化学情報印刷レポート · 研究参考用
Methyl cyanoacetate → methyl (2Z)-cyano[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl cyanoacetate | HCID 7747 | — |
| 反応物 | 5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione | HCID 2732752 | — |
| 生成物 | methyl (2Z)-cyano[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]acetate | HCID 67424559 | 77% |
反応手順
Following the general method as outlined for Intermediate 1, starting from 5-(trifluoromethoxy)-isatin and methyl cyanoacetate, the title compound was isolated, after evaporation, as a dark purple solid in 77% yield. This was a 7.5:1 mixture of geometric isomers.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08236963B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-0b8386fe95eb4640b6b24d51e763efa5 |
| 出典メモ | uspto-grants-2012_08 |